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pentobarbital decreases levels of panobinostat by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. Robust CYP3A4 inducers can lower panobinostat degrees by ~70% and lead to cure failure.pentobarbital will reduce the level or influence of naloxegol by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated.